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What chemicals must be reported on the High Hazard Chemical Registration Form?

A High Hazard Chemical is one which poses a potential health risk, described below, or is a reactive chemical which poses a physical risk. High hazard chemicals need to be reported on the High Hazard Chemical Registration Form and require that a written safety plan be prepared and followed when using these chemicals in vitro (in the laboratory) or in vivo (in animals).

Note: The following uses of chemical do not have to be reported as a high hazard chemical: antibiotics used to treat animal infections, anesthetics, analgesics.

The following chemicals are considered high hazardous chemicals due to the potential health effects;

  • Reproductive Toxins
  • Highly acutely toxic chemicals or a hazardous drug
  • Novel compounds of unknown toxicity

Select Carcinogens

A select carcinogen is any chemical that appears on the most current version of the following lists:

  • Chemicals regulated by OSHA as a carcinogen
  • Chemical known to be carcinogenic (Group 1) by the National Toxicity Program (NTP)
  • Chemicals listed as carcinogenic to humans by the International Agency on Research on Cancer (IARC)
  • Chemicals listed as reasonably anticipated to be carcinogenic by the NTP or the IARC (Groups 2A and 2B)

The following document list select carcinogens:

Reproductive Toxins

Chemicals which effect human reproductive capability because of chromosomal damage (mutagenic) or because of an adverse effect on the developing fetus (teratogenic).

The following document list reproductive toxins:

Highly Acute Toxic Chemicals or Hazardous Drugs

Chemicals known to be highly acutely toxic in humans or in comparable animal models as follows:

  • Chemicals with an oral median lethal dose (LD50 oral-rat) of 50 mg/kg or less.
  • Chemicals with a skin contact median lethal dose (LD50 skin-rabbit) of 200 mg/kg or less.
  • Chemicals with an inhalation toxicity (LC50-rat) of 200 ppm or 2 mg/L or less in 1 hour.

Novel Compounds of Unknown Toxicity

Chemicals which have not been tested for toxicity in any animal or other accepted testing protocol for assessing toxic effects and which by their structure are likely to be toxic, carcinogenic, mutagenic or teratogenic.

Chemicals Needing a Registration Form

Chemicals being used or proposed to be used at Tufts University are evaluated by TEHS for carcinogenicity and toxicity. Click Here to see the lists of chemicals that have been evaluated by TEHS and whether or not they require a written safety plan and a High Hazard Chemical Registration Form.

Click Here to download the High Hazard Chemical Registration Form form.

Back to Chemical Safety.